Ava Mackay-Smith
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Categories
ecological genetics
functional genomics
gene expression
human evolution
insect genetics
tool development

Research: Evolutionary Genetics and Gene Regulation

Background


I am a Ph.D. candidate in Duke University’s Program in Genetics and Genomics (UPGG) in Dr. Gregory Wray’s lab. My research interests revolve around evolutionary questions in the natural world, leveraging functional genomics methods to understand organismal adaptation and variation. To this end, my current work seeks to understand how epigenomic and structural factors interact to affect population genetics of hybridizing species in the diverse clade of Heliconius butterflies, in collaboration with teams at George Washington University and the Smithsonian Tropical Research Institute. I am also funded by a James B. Duke Fellowship and the National Science Foundation’s Graduate Research Fellowship.

I completed her undergraduate studies at Wellesley College, where I wrote an honors thesis in Dr. Andrea Sequeira’s lab on the transcriptomic responses and adaptation in an invasive, asexual beetle species. After leaving Wellesley, I moved to Dr. Pardis Sabeti’s lab at the Broad Institute of Harvard and MIT under the mentorship of Dr. Steve Reilly, working on human functional genomic characterization with the ENCODE Consortium. I then became the lab manager for the newly minted Reilly lab as it opened its doors at Yale in the fall of 2021. My work at Yale focused on the functional characterization of positively selected human variants, especially those within genetic regulatory elements, as well as consciously building the framework for an inclusive lab environment as the Reilly lab’s first member.

At Duke, I am involved in science communication and outreach programs such as the Carolinas Butterfly Monitoring Program and the Science Research and Education Network (SciREN). I am also a member of the Society of Duke Fellows. Outside of the lab, I enjoy horticulture, making coffee, watching standup comedy, learning to rollerblade, and hiking or backpacking.

Publications

Genome Mountaineering: Expanding Horizons of the 3D Genome for the Intrepid Evolutionary Adventurer
Jun 4, 2025

Multicenter integrated analysis of noncoding CRISPRi screens
Mar 19, 2024

The functional and evolutionary impacts of human-specific deletions in conserved elements
Jan 24, 2023

Genetically depauperate and still successful: few multilocus genotypes of the introduced parthenogenetic weevil Naupactus cervinus (Coleoptera: Curculionidae) prevail in the Continental United States
Jan 22, 2023

Host-specific gene expression as a tool for introduction success in Naupactus parthenogenetic weevils
Jul 30, 2021

Direct characterization of cis-regulatory elements and functional dissection of complex genetic associations using HCR-FlowFISH
Jul 29, 2021
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Copyright 2025, Ava Mackay-Smith

 

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